Overview

5-Amino-1MQ is a groundbreaking small molecule that inhibits the enzyme nicotinamide N-methyltransferase (NNMT), a critical regulator of metabolic function and energy balance, particularly in fat cells. By inhibiting NNMT, 5-Amino-1MQ increases levels of nicotinamide adenine dinucleotide (NAD+), a vital cofactor in cellular metabolism. This activation of NAD+ enhances the activity of the SIRT1 gene, also known as the “longevity gene,” due to its role in mitigating conditions like obesity, metabolic syndrome, cardiovascular disease, and neurodegenerative disorders.

Key Benefits of 5-Amino-1MQ

• Promotes Fat Burning: Enhances metabolism of white fat cells, leading to increased energy expenditure and reduction of fat deposits.
• Prevents Fat Accumulation: Regulates energy balance, reducing the storage of fat and preventing lipogenesis.
• Increases NAD+ Levels: Boosts NAD+, which is essential for cellular energy and overall metabolism.
• Supports Longevity: Activates SIRT1, reducing the risks of age-related diseases such as diabetes, obesity, and atherosclerosis.
• Improves Muscle Function: Supports muscle regeneration and function, making it ideal for those seeking improved muscle strength and recovery.

How It Works

NNMT is an enzyme highly active in fat tissues, where it plays a role in slowing metabolism. By inhibiting NNMT, 5-Amino-1MQ reduces fat cell size and decreases fat accumulation. It also enhances GLUT4 transporter expression, improving glucose metabolism and insulin sensitivity, critical factors in managing obesity and type 2 diabetes. Studies in animals have shown significant reductions in body mass without altering food intake, making this compound a powerful tool in weight management.

Clinical Applications

• Obesity Management: Reduces body fat and prevents further fat storage.
• Metabolic Conditions: Helps combat insulin resistance and type 2 diabetes by enhancing glucose regulation.
• Anti-Aging Support: Increases NAD+ levels, improving cellular energy and reducing age-related metabolic decline.
• Muscle Regeneration: Stimulates muscle stem cells, promoting faster recovery and enhanced muscle strength.
• Cognitive Support: Boosts NAD+ levels in the brain, potentially supporting cognitive function and preventing decline.

Dosage and Administration

• Recommended Dose: Inject 0.25 ml (150 μg) subcutaneously once daily for 20 days.
• Storage: Store in a freezer until first use. After opening, refrigerate between 2°C - 8°C for up to 60 days.
• Best Practices: For optimal results, administer 30 minutes after oral consumption of an NAD+ precursor, such as N-Riboside.

Research and Evidence

Animal studies have demonstrated the profound benefits of 5-Amino-1MQ in managing metabolic conditions. Mice treated with 5-Amino-1MQ showed a 7% reduction in body mass and a 30% decrease in fat mass within just 10 days, with no changes in food intake. The treatment also led to improved cholesterol levels, matching those of non-obese animals. These results suggest a powerful potential for 5-Amino-1MQ in addressing human obesity and related disorders.